Kazarians H, Scharein E, Bromm B
Department of Physiology, University Hospital Eppendorf, Hamburg, FRG.
Int J Neurosci. 1995 Mar;81(1-2):111-22. doi: 10.3109/00207459509015303.
Long latency brain potentials were evoked by infrared laser stimuli (LEPs) applied to the right forehead in order to activate the thinnest cutaneous A-delta afferents of the upper branch of the trigeminal nerve thus inducing a painful sensation. Ten healthy male subjects participated in 4 identical subsequent sessions, one week apart, receiving 4 blocks of 40 stimuli each. This way the individual trigeminal LEPs, as well as their inter- and intraindividual reliability were determined. Five major components could be identified, denoted by polarity and peak latencies: N150, P230, N300, P360, N480. The LEP waveforms were found to be highly stable within subjects, peak latencies varied by less than 5%. Great variation in waveform appeared amongst subjects, peak latencies varied by more than 15%. The last two components exhibited the largest variability and were not identified in all subjects.
通过将红外激光刺激（LEPs）施加于右前额来诱发长潜伏期脑电位，以激活三叉神经上支最细的皮肤A-δ传入神经，从而诱发疼痛感。10名健康男性受试者参加了后续4次相同的实验，每次间隔一周，每次接受4组，每组40次刺激。通过这种方式确定了个体三叉神经LEP及其个体间和个体内的可靠性。可以识别出五个主要成分，用极性和峰潜伏期表示：N150、P230、N300、P360、N480。发现LEP波形在受试者内部高度稳定，峰潜伏期变化小于5%。受试者之间波形出现很大差异，峰潜伏期变化超过15%。最后两个成分表现出最大的变异性，并非在所有受试者中都能识别出来。
