Scherl E R, Wilson J F
Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, USA.
Headache. 1995 May;35(5):256-9. doi: 10.1111/j.1526-4610.1995.hed3505256.x.
Migraineurs often seek office-based treatment for acute headache. To compare the efficacy and side effect profile, we entered 27 migraineurs into a prospective, randomized, double-blind study where each patient received either 75 mg meperidine with 25 mg promethazine IM or .5 mg dihydroergotamine with 10 mg metoclopramide IV. After 1 hour, pain relief was similar in the two groups, but side effects were significantly greater in the meperidine with promethazine regimen group. The dihydroergotamine with metoclopramide regimen is effective, and has minimal side effects, making it an attractive method for office-based treatment of acute migraine.
偏头痛患者常寻求门诊治疗急性头痛。为比较疗效和副作用情况，我们将27名偏头痛患者纳入一项前瞻性、随机、双盲研究，每位患者接受75毫克哌替啶加25毫克异丙嗪肌肉注射，或0.5毫克双氢麦角胺加10毫克甲氧氯普胺静脉注射。1小时后，两组的疼痛缓解情况相似，但哌替啶加异丙嗪治疗组的副作用明显更大。双氢麦角胺加甲氧氯普胺治疗方案有效且副作用最小，使其成为门诊治疗急性偏头痛的一种有吸引力的方法。
