Lane I F, Lappin M R, Seim H B
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA.
J Am Vet Med Assoc. 1995 May 1;206(9):1348-57.
Cytometrographic studies and urethral pressure profiles were performed to objectively assess the functional status of the urinary bladder and urethra in 9 dogs with congenital ectopic ureters. Functional abnormalities of the urinary bladder or urethra were detected in 8 of 9 (89%) dogs. Cystometrographic evidence of reduced bladder capacity was detected in 4 (44%) dogs, and abnormalities in urethral pressure profiles were consistent with urethral incompetence in 6 (67%) dogs. Dogs with urethral pressure profile abnormalities were treated with phenylpropanolamine hydrochloride, and the urethral pressure profile was reevaluated. Urethral pressure measurements obtained before surgery (3 dogs) and after phenylpropanolamine (6 dogs) were used to predict the likelihood of continence after surgery. Predicted outcomes included continence maintained without medication (3 dogs), continence maintained with phenylpropanolamine (2 dogs), and persistent incontinence despite phenylpropanolamine administration (4 dogs). After surgical repair of ectopic ureters, 2 of 9 (22%) dogs were continent without medication, and 2 (22%) maintained continence with phenylpropanolamine treatment. Various degrees of incontinence persisted in 5 of 9 (56%) dogs, 4 of which had urethral incompetence that had been documented as poorly responsive to phenylpropanolamine administration prior to surgery. Predicted outcomes were consistent with actual outcomes in 8 of 9 (89%) dogs, with predictions of incontinence proving accurate in 4 of 4 (100%) dogs and predictions of continence proving accurate in 4 of 5 (80%) dogs. Urodynamic assessment of dogs with ectopic ureters appears to be valuable for identifying concurrent functional abnormalities of the urinary bladder and urethra and for predicting postoperative outcome.
对9只患有先天性异位输尿管的犬进行了细胞计量学研究和尿道压力描记，以客观评估膀胱和尿道的功能状态。9只犬中有8只（89%）检测到膀胱或尿道功能异常。4只（44%）犬检测到膀胱容量减少的膀胱测压证据，6只（67%）犬尿道压力描记异常与尿道功能不全一致。对尿道压力描记异常的犬用盐酸苯丙醇胺治疗，并重新评估尿道压力描记。术前（3只犬）和服用苯丙醇胺后（6只犬）获得的尿道压力测量值用于预测术后控尿的可能性。预测结果包括无需药物维持控尿（3只犬）、服用苯丙醇胺维持控尿（2只犬）以及尽管服用苯丙醇胺仍持续失禁（4只犬）。异位输尿管手术修复后，9只犬中有2只（22%）无需药物即可控尿，2只（22%）通过苯丙醇胺治疗维持控尿。9只犬中有5只（56%）持续存在不同程度的失禁，其中4只术前记录为对苯丙醇胺治疗反应不佳的尿道功能不全。9只犬中有8只（89%）的预测结果与实际结果一致，4只预测失禁的犬中有4只（100%）预测准确，5只预测控尿的犬中有4只（80%）预测准确。对异位输尿管犬进行尿动力学评估似乎有助于识别膀胱和尿道并发的功能异常，并预测术后结果。
