RS - 22A、B和C：来自紫色链霉菌的新型大环内酯类抗生素。I. 分类学、发酵、分离及生物活性
RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.
作者信息
Ubukata M, Shiraishi N, Kobinata K, Kudo T, Yamaguchi I, Osada H, Shen Y C, Isono K
机构信息
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
出版信息
J Antibiot (Tokyo). 1995 Apr;48(4):289-92. doi: 10.7164/antibiotics.48.289.
PMID:7775264
Abstract
Three novel 36-membered macrolide antibiotics, RS-22A, B and C produced by Streptomyces violaceusniger have been isolated. These antibiotics were purified from an acetone extract of the mycelia followed by butanol extraction, centrifugal partition chromatography and HPLC. RS-22A, B, C showed antimicrobial activity against fungi and Gram-positive bacteria.
摘要
已分离出由紫色链霉菌产生的三种新型36元大环内酯类抗生素RS-22A、B和C。这些抗生素是从菌丝体的丙酮提取物中纯化得到的，随后经过丁醇萃取、离心分配色谱法和高效液相色谱法。RS-22A、B、C对真菌和革兰氏阳性菌显示出抗菌活性。
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