通过化学筛选获得的次生代谢产物：II. 阿霉素A和B，从高产伊索菌素和尼日利亚菌素菌株中分离出的两种新型尼菲霉素类似物。
Secondary metabolites by chemical screening: II. Amycins A and B two novel niphimycin analogs isolated from a high producer strain of elaiophylin and nigericin.
作者信息
Grabley S, Hammann P, Raether W, Wink J, Zeeck A
机构信息
Hoechst Aktiengesellschaft, Frankfurt a.M., FRG.
出版信息
J Antibiot (Tokyo). 1990 Jun;43(6):639-47. doi: 10.7164/antibiotics.43.639.
PMID:2257019
Abstract
Two novel natural niphimycin analogs, amycins A (5) and B (3) were isolated from the culture broth of the Streptomyces sp. DSM 3816 by chemical screening methods. In addition this strain produces the antibiotics niphimycin (4), elaiophylin (2) and nigericin (1). Fermentation, isolation, structure elucidation and biological activity of the amycins are described.
摘要
通过化学筛选方法，从链霉菌DSM 3816的培养液中分离出两种新型天然尼菲霉素类似物，即阿霉素A（5）和B（3）。此外，该菌株还产生抗生素尼菲霉素（4）、伊来霉素（2）和尼日利亚菌素（1）。本文描述了阿霉素的发酵、分离、结构解析及生物活性。
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