Calatayud O, Rodríguez M, Sánchez-Alcaraz A, Ibáñez P
Department of Laboratory, Lluis Alcanyis Hospital, Xativa, Spain.
J Clin Pharm Ther. 1995 Feb;20(1):23-9. doi: 10.1111/j.1365-2710.1995.tb00621.x.
Caffeine elimination was studied in 73 patients admitted to an intensive care unit, 33 of whom had liver disease. Mean plasma clearance of caffeine in patients with no liver disease (1.30 +/- 0.79 ml/kg/min) was significantly higher than in patients with liver disease (0.39 +/- 0.23 ml/kg/min). Mean half-life of caffeine in patients with liver disease (23.96 +/- 12.19 h) was significantly higher than in patients with no liver disease (7.25 +/- 3.04 h). No significant differences in distribution volumes were found. Receptor-operator curves (ROC) for plasma clearance and the half-life of elimination of caffeine showed a high diagnostic value. Therefore, the parameters for caffeine biotransformation, i.e. Cl and t1/2, are useful for assessing liver function in the population studied.
