Braekhus A, Laake K, Engedal K
Research Group in Geriatrics of the Norwegian National Health Association, Ullevaal Hospital, Oslo.
J Am Geriatr Soc. 1995 Jun;43(6):656-61. doi: 10.1111/j.1532-5415.1995.tb07201.x.
To study whether a low, "normal" sumscore (i.e., 24 or higher) on the Mini-Mental Status Examination (MMSE) near the cutpoint usually employed for identifying persons with cognitive impairment predicts later development of dementia.
A prospective study of a random sample of nondemented persons aged 75 years and older, according to DSM-III criteria, with follow-ups after 3 and 6 years.
The subjects were 215 persons living at home, mean age 81 years, 81% women. Their mean MMSE sumscore at the start of the study (T0) was 27.9 (range 24-30).
A low MMSE sumscore at T0 was identified as a statistically strongly significant predictor of dementia after 3 years (P < .001), when more than 40% of those with a sumscore of 24 or 25 at T0 had become demented. A similar, although weaker and statistically nonsignificant, trend was observed for the risk after 6 years in relation to MMSE scoring at baseline.
Persons with a sumscore of 24 or 25 and classified as not suffering from dementia according to the DSM-III criteria are at high risk of developing dementia within 3 years.
研究在通常用于识别认知障碍患者的简易精神状态检查表（MMSE）临界值附近获得低的、“正常”总分（即24分或更高）是否能预测痴呆症的后期发展。
根据《精神疾病诊断与统计手册》第三版（DSM-III）标准，对75岁及以上非痴呆患者的随机样本进行前瞻性研究，并在3年和6年后进行随访。
受试者为215名居家老人，平均年龄81岁，81%为女性。研究开始时（T0）他们的MMSE总分平均为27.9分（范围24 - 30分）。
T0时低MMSE总分被确定为3年后痴呆症的一个具有统计学显著意义的强预测指标（P <.001），T0时总分24分或25分的患者中超过40%在3年后已患痴呆症。在6年后的风险方面，观察到与基线MMSE评分相关的类似趋势，尽管较弱且无统计学意义。
根据DSM-III标准总分在24分或25分且被归类为未患痴呆症的人群在3年内患痴呆症的风险很高。
