Kacica M A, Venezia R A, Miller J, Hughes P A, Lepow M L
Department of Pediatrics, Albany Medical College, NY 12208, USA.
J Med Virol. 1995 Feb;45(2):227-9. doi: 10.1002/jmv.1890450220.
The present investigation was done to determine whether measles enzyme immune assay (EIA) absorbency values were lower in women born in the vaccine era after 1963 and their infants in an upstate New York metropolitan area, an area of low measles incidence during the past 10 years compared with women born before the measles vaccine era who had natural measles. Aliquots of 202 sera from mother-infant pairs collected for other purposes from November 1990 to June 1991 at Albany Medical Center Hospital were tested by EIA. The demographic data available for analysis were maternal age and infant gestational age. Measles mean absorbency values were analyzed according to maternal age. Of 202 mother-infant pairs, 30% of mothers and 17% of their infants were seronegative (EIA < 0.16). Mothers born before 1963 and their infants had significantly higher mean EIA absorbency values than mothers born after 1963 and their infants (P < 0.002). The percent seropositive for measles antibodies by EIA for mothers born before 1963 and their infants, 87% and 94%, respectively, was significantly higher than the percent seropositive for mothers born after 1963 and their infants, 61% and 69%, respectively (P = 0.0001). Since the mean measles antibodies as measured by EIA absorbency were significantly lower in the mothers born after 1963 and their infants compared with women born before the vaccine era, the strategy for measles control in the future may have to include lowering the age of infant immunization.
本研究旨在确定1963年后疫苗时代出生的纽约州北部大都市地区的女性及其婴儿的麻疹酶免疫测定（EIA）吸光度值是否低于麻疹疫苗时代之前自然感染麻疹的女性。1990年11月至1991年6月在奥尔巴尼医疗中心医院采集的202对母婴血清样本，用于其他目的，采用EIA进行检测。可用于分析的人口统计学数据为母亲年龄和婴儿孕周。根据母亲年龄分析麻疹平均吸光度值。在202对母婴中，30%的母亲和17%的婴儿血清学阴性（EIA＜0.16）。1963年前出生的母亲及其婴儿的平均EIA吸光度值显著高于1963年后出生的母亲及其婴儿（P＜0.002）。1963年前出生的母亲及其婴儿通过EIA检测的麻疹抗体血清阳性率分别为87%和94%，显著高于1963年后出生的母亲及其婴儿，分别为61%和69%（P = 0.0001）。由于1963年后出生的母亲及其婴儿通过EIA吸光度测量的平均麻疹抗体显著低于疫苗时代之前出生的女性，未来麻疹控制策略可能必须包括降低婴儿免疫接种年龄。
