血管紧张素II片段（天冬氨酸-精氨酸-缬氨酸-酪氨酸-异亮氨酸-组氨酸和精氨酸-缬氨酸-酪氨酸-异亮氨酸-组氨酸）与铜（II）的结合：金属离子锚定过程中氨基与咪唑氮之间的竞争。

Cu(II) binding by angiotensin II fragments: Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His. Competition between amino group and imidazole nitrogens in anchoring of metal ions.

作者信息

Bal W, Jezowska-Bojczuk M, Kozlowski H, Chruscinski L, Kupryszewski G, Witczuk B

机构信息

Institute of Chemistry, University of Wroclaw, Poland.

出版信息

J Inorg Biochem. 1995 Mar;57(4):235-47. doi: 10.1016/0162-0134(94)00026-7.

DOI:10.1016/0162-0134(94)00026-7

PMID:7775978

Abstract

Potentiometric and spectroscopic (absorption, circular dichroism and electron paramagnetic resonance) study on the coordination of two angiotensin II fragments (Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His) to Cu(II) ions has shown that competition between amino and imidazole nitrogens to anchor metal ions is a complicated process and may lead to formation of macrochelate rings. The important factor that influences this competition is the distance between competing His and N-terminal residues (number of spacer residues in a peptide sequence).

摘要

对两种血管紧张素II片段（天冬氨酸-精氨酸-缬氨酸-酪氨酸-异亮氨酸-组氨酸和精氨酸-缬氨酸-酪氨酸-异亮氨酸-组氨酸）与铜（II）离子配位的电位滴定和光谱研究（吸收光谱、圆二色光谱和电子顺磁共振光谱）表明，氨基氮和咪唑氮在锚定金属离子方面的竞争是一个复杂的过程，可能会导致大环螯合环的形成。影响这种竞争的一个重要因素是相互竞争的组氨酸残基和N端残基之间的距离（肽序列中间隔残基的数量）。