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母亲在孕期(经胎盘)使用醋酸氟卡尼治疗胎儿心动过速和胎儿水肿后,新生儿出现结合胆红素血症。

Conjugated hyperbilirubinemia in a newborn infant after maternal (transplacental) treatment with flecainide acetate for fetal tachycardia and fetal hydrops.

作者信息

Vanderhal A L, Cocjin J, Santulli T V, Carlson D E, Rosenthal P

机构信息

Division of Neonatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

出版信息

J Pediatr. 1995 Jun;126(6):988-90. doi: 10.1016/s0022-3476(95)70230-x.

DOI:10.1016/s0022-3476(95)70230-x
PMID:7776114
Abstract

An infant with intrauterine supraventricular tachycardia and fetal hydrops, successfully treated with administration of flecainide acetate to the mother had conjugated hyperbilirubinemia shortly after birth. An extensive evaluation failed to disclose a known cause. We believe that in utero exposure to flecainide acetate resulted in conjugated hyperbilirubinemia in this infant.

摘要

一名患有宫内室上性心动过速和胎儿水肿的婴儿,通过给母亲使用醋酸氟卡尼成功治疗,但出生后不久出现了结合胆红素血症。广泛评估未能发现已知病因。我们认为,该婴儿在子宫内接触醋酸氟卡尼导致了结合胆红素血症。

相似文献

1
Conjugated hyperbilirubinemia in a newborn infant after maternal (transplacental) treatment with flecainide acetate for fetal tachycardia and fetal hydrops.母亲在孕期(经胎盘)使用醋酸氟卡尼治疗胎儿心动过速和胎儿水肿后,新生儿出现结合胆红素血症。
J Pediatr. 1995 Jun;126(6):988-90. doi: 10.1016/s0022-3476(95)70230-x.
2
Direct intrauterine fetal treatment of fetal tachyarrhythmia with severe hydrops fetalis by antiarrhythmic drugs.通过抗心律失常药物对患有严重胎儿水肿的胎儿心动过速进行直接宫内胎儿治疗。
Fetal Ther. 1988;3(4):210-5. doi: 10.1159/000263358.
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Transplacental flecainide therapy for fetal supraventricular tachycardia in a twin pregnancy.双胎妊娠中经胎盘应用氟卡尼治疗胎儿室上性心动过速
Aust N Z J Obstet Gynaecol. 1999 Feb;39(1):110-2. doi: 10.1111/j.1479-828x.1999.tb03458.x.
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Flecainide treatment of fetal tachycardia and hydrops fetalis in a twin pregnancy.
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Refractory supraventricular fetal tachycardia as a cause of non-immune hydrops: management conundrum.作为非免疫性水肿原因的难治性胎儿室上性心动过速:治疗难题。
BMJ Case Rep. 2023 Dec 28;16(12):e255808. doi: 10.1136/bcr-2023-255808.
6
Unusual electrocardiogram findings in a preterm infant after fetal tachycardia with hydrops fetalis treated with flecainide.胎儿心动过速合并胎儿水肿的早产婴儿经氟卡尼治疗后出现异常心电图表现。
Pediatr Cardiol. 2000 May-Jun;21(3):259-62. doi: 10.1007/s002460010053.
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Fetal supraventricular tachycardia and hydrops fetalis: combined intensive, direct, and transplacental therapy.胎儿室上性心动过速与胎儿水肿:强化、直接及经胎盘联合治疗
Obstet Gynecol. 1991 Sep;78(3 Pt 2):523-5.
8
Refractory Fetal Supraventricular Tachycardia with Hydrops Successfully Converted by Intraperitoneal Flecainide in the Fetus: A Case Report.胎儿腹腔内氟卡尼治疗难治性胎儿室上性心动过速伴水肿:病例报告。
Fetal Diagn Ther. 2020;47(9):717-720. doi: 10.1159/000508811. Epub 2020 Jun 22.
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Maternal administration of flecainide to terminate and suppress fetal tachycardia.母体使用氟卡尼以终止和抑制胎儿心动过速。
Br Med J (Clin Res Ed). 1988 Jan 23;296(6617):249. doi: 10.1136/bmj.296.6617.249.
10
Successful treatment of supraventricular tachycardia exhibiting hydrops fetalis with flecainide acetate. A case report.醋酸氟卡尼成功治疗表现为胎儿水肿的室上性心动过速。病例报告。
Fetal Diagn Ther. 2003 Mar-Apr;18(2):83-6. doi: 10.1159/000068066.

引用本文的文献

1
Transplacental pharmacokinetics of flecainide in the gravid baboon and fetus.氟卡尼在妊娠狒狒和胎儿体内的经胎盘药代动力学。
Pediatr Cardiol. 2005 Nov-Dec;26(6):815-20. doi: 10.1007/s00246-005-0974-8.
2
Drug treatment of fetal tachycardias.胎儿心动过速的药物治疗。
Paediatr Drugs. 2002;4(1):49-63. doi: 10.2165/00128072-200204010-00006.
3
Treatment of cardiac arrhythmias during pregnancy: safety considerations.孕期心律失常的治疗:安全性考量
Drug Saf. 1999 Jan;20(1):85-94. doi: 10.2165/00002018-199920010-00008.
4
Adverse effects of class I antiarrhythmic drugs.I类抗心律失常药物的不良反应。
Drug Saf. 1997 Jul;17(1):8-36. doi: 10.2165/00002018-199717010-00002.