Hallak M, Neerhof M G, Perry R, Nazir M, Huhta J C
Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia.
Obstet Gynecol. 1991 Sep;78(3 Pt 2):523-5.
A 25-week fetus with severe hydrops fetalis secondary to supraventricular tachycardia was treated with fetal intramuscular injections of digoxin in conjunction with maternal intravenous digoxin, followed by oral digoxin and subsequently by oral procainamide therapy. Fetal umbilical blood sampling revealed poor placental transfer of digoxin, even after 2 weeks of therapeutic maternal levels. This case suggests that direct fetal therapy is of value in the treatment of some fetuses with supraventricular tachycardia, and lends further evidence that the role of transplacental digoxin therapy is limited in the compromised fetus. It also demonstrates that resolution of hydrops may require a prolonged period.
一名25周大的胎儿因室上性心动过速继发严重胎儿水肿，接受了胎儿肌肉注射地高辛并联合母亲静脉注射地高辛治疗，随后口服地高辛，接着口服普鲁卡因胺治疗。胎儿脐血取样显示，即使母亲达到治疗水平2周后，地高辛的胎盘转运情况仍不佳。该病例表明，直接胎儿治疗对某些室上性心动过速胎儿的治疗具有价值，进一步证明了胎盘转运地高辛治疗在受损胎儿中的作用有限。它还表明，水肿的消退可能需要较长时间。
