Miyakawa H, Iwasaka H, Mori M, Oda S, Taniguchi K, Honda N
Department of Anesthesiology, Oita Medical University.
Masui. 1995 Apr;44(4):522-5.
In 10 consented patients (ASA I-II) we quantitated the hypnotic potencies of 0.7 MAC nitrous oxide and 0.7 MAC sevoflurane by measuring auditory evoked response (AER), and compared the hypnotic potency of nitrous oxide with that of sevoflurane at the same MAC. In each patient, measurements of AER waves were performed in the following three stages, 0.7 MAC nitrous oxide, 0.7 MAC sevoflurane and 0.7 MAC nitrous oxide after induction of anesthesia. Analysis of variance was used to compare the hypnotic potencies between two inhaled anesthetics. Pa and Nb latencies with sevoflurane were longer than those with nitrous oxide, and Pa and Nb amplitudes with sevoflurane were greater than those with nitrous oxide. However, we found that there were no statistical significances in our results. In conclusion, nitrous oxide exerts as much hypnotic effect as sevoflurane.
在10例签署知情同意书的患者（美国麻醉医师协会身体状况分级I-II级）中，我们通过测量听觉诱发电位（AER）来定量0.7倍最低肺泡有效浓度（MAC）的氧化亚氮和0.7倍MAC的七氟醚的催眠效能，并比较相同MAC下氧化亚氮与七氟醚的催眠效能。在每位患者中，分别在以下三个阶段进行AER波测量：0.7倍MAC的氧化亚氮、0.7倍MAC的七氟醚以及麻醉诱导后的0.7倍MAC的氧化亚氮。采用方差分析比较两种吸入麻醉药的催眠效能。七氟醚组的Pa和Nb潜伏期长于氧化亚氮组，七氟醚组的Pa和Nb波幅大于氧化亚氮组。然而，我们发现结果无统计学意义。总之，氧化亚氮与七氟醚具有相同的催眠效果。
