Yurino M, Kimura H
Department of Anesthesiology and Resuscitology, Asahikawa Medical College, Hokkaido, Japan.
Acta Anaesthesiol Scand. 1995 Apr;39(3):356-8. doi: 10.1111/j.1399-6576.1995.tb04077.x.
A previous investigation using nitrous oxide with 5% enflurane (3.8 MAC) for single breath induction produced a stage of excitement which may be related to the difference in blood/gas coefficient solubility of these agents. The closer blood/gas solubility coefficient of sevoflurane and nitrous oxide may eliminate this phenomenon. We therefore evaluated 40 volunteers in a randomized study using 7.5% sevoflurane (3.7 MAC) in oxygen (n = 21) or sevoflurane with nitrous oxide (n = 19) using a single breath induction technique. Sevoflurane in nitrous oxide and oxygen reduced induction time by 15% compared to sevoflurane in oxygen alone (41 +/- 16 and 48 +/- 16 sec (s.d.), respectively). This was, however, not statistically significant. There were scarcely induction-related complications, such as coughing, laryngospasm, breath-holding, movements of a limb and excessive salivation, in either group. Thus, the addition of nitrous oxide neither increased the number of complications, nor the speed of induction.
先前一项研究使用氧化亚氮与5%安氟醚（3.8最低肺泡有效浓度）进行单次呼吸诱导，产生了兴奋期，这可能与这些药物血/气系数溶解度的差异有关。七氟醚和氧化亚氮更接近的血/气溶解度系数可能会消除这种现象。因此，我们在一项随机研究中评估了40名志愿者，采用单次呼吸诱导技术，一组使用7.5%七氟醚（3.7最低肺泡有效浓度）与氧气混合（n = 21），另一组使用七氟醚与氧化亚氮混合（n = 19）。与仅使用氧气的七氟醚相比，七氟醚与氧化亚氮和氧气混合可使诱导时间缩短15%（分别为41±16秒和48±16秒（标准差））。然而，这在统计学上并不显著。两组中几乎都没有出现与诱导相关的并发症，如咳嗽、喉痉挛、屏气、肢体运动和唾液分泌过多。因此，添加氧化亚氮既没有增加并发症的数量，也没有加快诱导速度。
