Ibáñez C F, Rydén M
Avdelningen för molekylär neurobiologi, Karolinska institutet, Stockholm.
Lakartidningen. 1995 May 24;92(21):2191-4.
The development and maintenance of the vertebrate nervous system requires a continuous supply of a number of polypeptide hormones known as neurotrophic factors. The ability of neurotrophic factors to promote the survival of peripheral and central neurons during development and after neuronal damage has aroused interest in these molecules as potential therapeutic agents for the treatment of nervous lesions and neurodegenerative diseases. Understanding of the molecular basis of the biological specificity of neurotrophic polypeptides has provided insight into their mechanisms of action and allowed strategies to be developed for the rational design of derivatives and analogues with specific pharmacological properties.
脊椎动物神经系统的发育和维持需要持续供应多种被称为神经营养因子的多肽激素。神经营养因子在神经元发育过程中和神经元损伤后促进外周和中枢神经元存活的能力，引发了人们对这些分子作为治疗神经损伤和神经退行性疾病潜在治疗剂的兴趣。对神经营养多肽生物学特异性分子基础的理解，为深入了解其作用机制提供了思路，并使得开发具有特定药理特性的衍生物和类似物的合理设计策略成为可能。
