Ibáñez C F
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Trends Biotechnol. 1995 Jun;13(6):217-27. doi: 10.1016/S0167-7799(00)88949-0.
The development and maintenance of the vertebrate nervous system requires the continuous supply of a number of polypeptide hormones known as neurotrophic factors. The ability of neurotrophic factors to promote the survival of peripheral and central neurones during development and after neuronal damage, has stimulated an interest in these molecules as potential therapeutic agents for the treatment of nerve injuries and neurodegenerative diseases. Understanding the molecular basis of the biological specificity of neurotrophic polypeptides has provided an insight into their mechanisms of action, and allowed the design of derivatives and analogues with specific pharmacological properties.
脊椎动物神经系统的发育和维持需要持续供应多种被称为神经营养因子的多肽激素。神经营养因子在发育过程中和神经元损伤后促进外周和中枢神经元存活的能力，激发了人们对这些分子作为治疗神经损伤和神经退行性疾病潜在治疗剂的兴趣。了解神经营养多肽生物学特异性的分子基础，有助于深入了解其作用机制，并有助于设计具有特定药理特性的衍生物和类似物。
