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苯妥英钠对家兔视觉皮层神经元反应及学习过程中行为的影响。

Influence of dilantin on the reactions of neurons of the visual cortex and the behavior of rabbits during learning.

作者信息

Shul'gina G I

机构信息

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.

出版信息

Neurosci Behav Physiol. 1995 Jan-Feb;25(1):7-14. doi: 10.1007/BF02359244.

Abstract

Changes in behavior in response to light flashes, the conditional stimulus of a defense reflex, were not observed following the administration of dilantin, a preparation which attenuates posttetanic potentiation, in rabbits with preliminarily developed defense and inhibitory conditioned reflexes; weak disinhibition of movements appeared in response to the action of flashes against the background of a conditional inhibitor. The similarity of the reactions of the neurons of the visual cortex to light flashes, the CS, with the responses to their joint action with the reinforcement, did not weaken in the majority of instances, while in several neurons, it intensified. The differences in the responses to reinforced and inhibitory light flashes did not disappear following the administration of dilantin, but they attenuated in some of the neurons due to filling of the inhibitory pause with impulses. The results obtained make it possible to draw the conclusion that posttetanic potentiation does not participate in the maintenance of developed conditioned reflexes.

摘要

在预先建立了防御性和抑制性条件反射的家兔中,给予能减弱强直后增强作用的药物苯妥英钠后,未观察到家兔对闪光(防御反射的条件刺激)的行为反应有变化;在条件抑制的背景下,对闪光的作用出现了微弱的运动去抑制。在大多数情况下,视觉皮层神经元对闪光(条件刺激)的反应与对闪光和强化刺激联合作用的反应之间的相似性并未减弱,而在一些神经元中,这种相似性增强了。给予苯妥英钠后,对强化和抑制性闪光反应的差异并未消失,但在一些神经元中,由于抑制性暂停被冲动填充,这些差异有所减弱。所获得的结果使得可以得出结论:强直后增强不参与已建立的条件反射的维持。

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