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[乙醇对正在学习的家兔视觉皮层兴奋和抑制过程的影响]

[Effect of ethanol on excitatory and inhibitory processes in the visual cortex of rabbits undergoing learning].

作者信息

Shul'gina G I, Nikiforov I V, Saakian S A

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1988 Mar-Apr;38(2):275-84.

PMID:2840784
Abstract

Subcutaneous ethanol injection to waking rabbits in a dose of 2-6 g/kg causes discoordination of movements, a decline in motor reactions to inhibitory and reinforced light flashes, and appearance of equalizing and paradoxical relations in the number of reactions to these stimuli. Under the influence of ethanol, activating and disinhibitory action of the pain reinforcement on neurones of the visual area temporarily weakens, while the disinhibitory influence of light flashes (CS) is preserved. Judging from the dynamics of phasic reactions to the inhibitory light flashes, the ethanol in a dose of 2-6 g/kg does not influence the inhibitory hyperpolarization processes in the cerebral cortex of rabbits. Tonic inhibition of the cortical unit activity temporarily intensifies after the ethanol injection.

摘要

给清醒的兔子皮下注射2 - 6克/千克剂量的乙醇,会导致运动失调、对抑制性和强化性光闪烁的运动反应下降,以及对这些刺激的反应数量出现均衡和反常关系。在乙醇的影响下,疼痛强化对视觉区域神经元的激活和去抑制作用暂时减弱,而光闪烁(条件刺激)的去抑制影响则得以保留。从对抑制性光闪烁的相位反应动态来看,2 - 6克/千克剂量的乙醇不会影响兔子大脑皮层的抑制性超极化过程。乙醇注射后,皮层单位活动的紧张性抑制会暂时增强。

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