脑池内注射生长抑素2、3和5型受体亚型对清醒大鼠胃酸分泌的影响。

Influence of intracisternal injection of somatostatin analog receptor subtypes 2, 3 and 5 on gastric acid secretion in conscious rats.

作者信息

Martínez V, Coy D H, Taché Y

机构信息

CURE/Gastroenteric Biology Center, VA Medical Center, UCLA 90073, USA.

出版信息

Neurosci Lett. 1995 Feb 17;186(2-3):79-82. doi: 10.1016/0304-3940(95)11286-6.

DOI:10.1016/0304-3940(95)11286-6

PMID:7777203

Abstract

Somatostatin (SST) and its analogs injected into the CSF induce different gastric acid response patterns. Five SST receptors have been characterized (SSTR-1 to -5). We studied the influence of selective SSTR-2, -3 and -5 ligands on basal gastric acid secretion after intracisternal (i.c.) injection in conscious rats equipped with chronic gastric and i.c. cannulae. Compared with pre-injection level, the SSTR-3 agonist, BIM-23056 (1 microgram) increased acid secretion by 274 +/- 43% while the SSTR-2 agonist, DC 32-87 (1 microgram) inhibited acid secretion by 50.7 +/- 13.3%. SST-14 (1 microgram), the SSTR-5 agonist, BIM-23052, (0.5-1 microgram), SSTR-3 (0.5 micrograms) and -2 (0.5 microgram) or vehicle injected i.c. did not modify basal acid secretion. These results show that the activation of brainstem SSTR-3 receptors stimulate and SSTR-2 inhibit basal gastric acid secretion in conscious rats with chronic gastric fistulae.

摘要

向脑脊液中注射生长抑素（SST）及其类似物会引发不同的胃酸反应模式。已鉴定出五种SST受体（SSTR - 1至 - 5）。我们研究了选择性SSTR - 2、 - 3和 - 5配体对经慢性胃和脑池插管的清醒大鼠脑池内（i.c.）注射后基础胃酸分泌的影响。与注射前水平相比，SSTR - 3激动剂BIM - 23056（1微克）使胃酸分泌增加了274±43%，而SSTR - 2激动剂DC 32 - 87（1微克）则使胃酸分泌抑制了50.7±13.3%。脑池内注射SST - 14（1微克）、SSTR - 5激动剂BIM - 23052（0.5 - 1微克）、SSTR - 3（0.5微克）和 - 2（0.5微克）或溶剂均未改变基础胃酸分泌。这些结果表明，在有慢性胃瘘的清醒大鼠中，脑干SSTR - 3受体的激活会刺激基础胃酸分泌，而SSTR - 2则会抑制基础胃酸分泌。