Panova I G, Burlakova O V, Stroeva O G
Ontogenez. 1994 Nov-Dec;25(6):47-53.
The activity of melanin-aggregating hormones (MAH) in the blood serum and homogenates of the eyes in four strains of rats was determined using the method of bioassay on dermal melanophores of tadpoles (Rana temporaria). This test-system is sensitive to melatonin at concentration of 25.1 mg/ml and higher. MAH is detected in the blood at 9th and in eye homogenates at 15th days after birth in grey Norway rats, while in albino Wistar and pale hooded Campbell rats with hereditary retinal degeneration MAH is observed at the 3rd and 4th postnatal days respectively. No increase of MAH activity is found in black hooded Hunter rats with inherent retinal degeneration during the first five days after birth. Thus, Wistar and Campbell rats differ significantly from grey and Hunter rats by MAH activity in the blood and eyes during early postnatal development.
采用对蝌蚪（林蛙）皮肤黑素细胞进行生物测定的方法，测定了四种品系大鼠血清和眼匀浆中黑色素聚集激素（MAH）的活性。该测试系统对浓度为25.1毫克/毫升及以上的褪黑素敏感。在出生后第9天，灰色挪威大鼠血液中检测到MAH，在出生后第15天眼匀浆中检测到MAH；而在患有遗传性视网膜变性的白化Wistar大鼠和浅色带帽坎贝尔大鼠中，分别在出生后第3天和第4天观察到MAH。在出生后前五天，患有先天性视网膜变性的黑色带帽亨特大鼠中未发现MAH活性增加。因此，在出生后早期发育过程中，Wistar大鼠和坎贝尔大鼠在血液和眼睛中的MAH活性与灰色大鼠和亨特大鼠有显著差异。
