Bock B C, Kanarek R B, Aprille J R
Department of Psychology, Tufts University, Medford, MA 02155, USA.
Physiol Behav. 1995 Apr;57(4):659-68. doi: 10.1016/0031-9384(94)00312-2.
The effects of dietary mineral levels on caloric intake, nutrient choice, body weight, adipose tissue weight, interscapular brown adipose tissue (IBAT) weight, and thermogenic capacity, and plasma insulin and glucose levels were examined in adult male Sprague-Dawley rats. In Experiments 1 and 2, rats were fed a purified diet with zinc (Zn), chromium (Cr), and selenium (Se) added, or the same diet without the addition of these minerals. In Experiment 3, the effects of Zn and Cr were examined separately. In all experiments, half of the rats in each diet group were given a 32% sucrose solution in addition to their standard diet and water. Rats given sucrose consumed more calories and gained more weight than rats not given sucrose. However, mineral levels altered the effects of sucrose on these measures. Added minerals increased percent sucrose intake, reduced weight gain and feed efficiency, increased GDP binding in IBAT mitochondria, improved glucose tolerance, and reduced plasma insulin levels. The reduction in weight gain and increased feed efficiency found when Zn alone was added to the diet was independent of sucrose condition. In comparison, the alterations observed in these measures when Cr alone was added to the diet varied as a function of sucrose availability.
在成年雄性斯普拉格-道利大鼠中，研究了日粮矿物质水平对热量摄入、营养选择、体重、脂肪组织重量、肩胛间棕色脂肪组织（IBAT）重量、产热能力以及血浆胰岛素和葡萄糖水平的影响。在实验1和实验2中，给大鼠喂食添加了锌（Zn）、铬（Cr）和硒（Se）的纯化日粮，或不添加这些矿物质的相同日粮。在实验3中，分别研究了锌和铬的影响。在所有实验中，每个日粮组的一半大鼠除了标准日粮和水之外，还给予32%的蔗糖溶液。给予蔗糖的大鼠比未给予蔗糖的大鼠消耗更多热量且体重增加更多。然而，矿物质水平改变了蔗糖对这些指标的影响。添加的矿物质增加了蔗糖摄入量百分比，降低了体重增加和饲料效率，增加了IBAT线粒体中的GDP结合，改善了葡萄糖耐量，并降低了血浆胰岛素水平。日粮中单独添加锌时体重增加的减少和饲料效率的提高与蔗糖条件无关。相比之下，日粮中单独添加铬时，这些指标的变化随蔗糖可用性而变化。
