Denton D A, Blair-West J R, McBurnie M, Weisinger R S, Logan A, Gonzales A M, Baird A
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Physiol Behav. 1995 Apr;57(4):747-52. doi: 10.1016/0031-9384(94)00319-x.
Intracerebroventricular (ICV) infusion of basic fibroblast growth factor (FGF-2) at 50 ng/h for 5 days in male BALB/c mice suppressed the daily intakes of water and food (n = 4). Intakes were reduced on the second day, and were suppressed until the second day after stopping the infusion. The same infusion for 4 days had little effect on the high intakes of 0.3 M NaCl solution and water induced by prolonged ICV infusion of angiotensin II, or the daily food intake in these experiments (n = 7). However, the same infusion for 3-4 days reduced the increased intake of NaCl solution in Na-depleted mice (n = 8), reduced the increased water intake of water-restricted mice (n = 6 or n = 7), and reduced daily food intake in both experiments. Ventricular enlargement was noted in mice at the end of these experiments but, for reasons advanced, did not appear to account for the responses. The results indicate that FGF-2 may have an inhibitory role in these ingestive behaviours.
在雄性BALB/c小鼠中，以50纳克/小时的速度脑室内（ICV）注入碱性成纤维细胞生长因子（FGF - 2），持续5天，抑制了水和食物的每日摄入量（n = 4）。摄入量在第二天减少，并一直被抑制到停止注入后的第二天。在这些实验中，同样注入4天对由长时间脑室内注入血管紧张素II诱导的0.3 M NaCl溶液和水的高摄入量或每日食物摄入量几乎没有影响（n = 7）。然而，同样注入3 - 4天减少了钠缺乏小鼠中NaCl溶液摄入量的增加（n = 8），减少了限水小鼠中饮水量的增加（n = 6或n = 7），并且在两个实验中都减少了每日食物摄入量。在这些实验结束时，小鼠出现脑室扩大，但由于上述原因，这似乎并不能解释这些反应。结果表明，FGF - 2可能在这些摄食行为中具有抑制作用。
