Glise H, Hallerbäck B, Johansson B
Dept. of Surgery, NAL., Trollhättan, Sweden.
Scand J Gastroenterol Suppl. 1995;208:133-5. doi: 10.3109/00365529509107775.
It has recently been suggested that Quality of Life (QOL) be used in the evaluation of new medical treatment regimens together with cost-benefit, efficacy and safety. In this overview we point out some aspects of use of the Psychological General Well-Being Index (PGWB) in patients with peptic ulcer and reflux disease gained from our own investigations in later years.
QOL was assessed using questionnaires before diagnosis, during medical healing treatment and at a 1-year follow-up in peptic ulcer disease or before and after surgery in reflux disease.
Untreated patients with unknown diagnosis had low QOL scores. With treatment, scores increased rapidly to supernormal values and fell off to normal values during the follow-up year.
QOL evaluations seem sensitive and reflect the patient's subjective feeling of disease. They add another new aspect of treatment effect not earlier included in treatment evaluations.
最近有人建议，在评估新的药物治疗方案时，应将生活质量（QOL）与成本效益、疗效和安全性一起使用。在本综述中，我们指出了近年来我们自己的研究中获得的心理总体幸福感指数（PGWB）在消化性溃疡和反流性疾病患者中的一些使用方面。
在消化性溃疡疾病诊断前、药物愈合治疗期间和1年随访时，或在反流性疾病手术前后，使用问卷评估生活质量。
诊断不明的未治疗患者生活质量得分较低。经过治疗，得分迅速升至超常值，并在随访年度降至正常值。
生活质量评估似乎很敏感，能反映患者对疾病的主观感受。它们增加了治疗效果评估中以前未包括的另一个新方面。
