Bakta I M, Budhianto F X
Department of Internal Medicine, Udayana University, Denpasar, Indonesia.
Southeast Asian J Trop Med Public Health. 1994 Sep;25(3):459-63.
A cross sectional study was conducted in Jagapati Village, Bali to assess some characteristics of hookworm anemia among the adult population. Hookworm anemia was defined as an iron deficiency anemia in heavily infected individuals (EPG > 2,000). WHO criteria for anemia and criteria of Hercberg for iron deficiency were used. In this study, 15 cases of hookworm anemia were found among 454 total samples (3.3%), or among 123 cases of iron deficiency anemia (12.2%). The age varied between 16-69 years with male to female ratio of 1:2.8. Twelve cases were found with symptoms and signs of anemia, 1 case with full blown hookworm anemia, and 2 cases were asymptomatic. The hemoglobin level was found to be 4.5-12.9 g/dl, with 12 cases (80.0%) being classified as mild anemia, 2 cases (13.3%) as moderate anemia, and 1 case as severe anemia. The mean serum iron level was 39.6 mg/dl, mean transferrin saturation was 11.1%, and mean serum ferritin level was 9.6 ng/dl. Hypoalbuminemia was found in 9 cases (60.0%), eosinophilia in 8 cases (53.3%), and low serum folic acid level in 5 cases (38.5%). High total serum IgE level was found in all but one case, with mean total serum IgE level of 3,739 U/ml. The intensity of hookworm infection was moderate in 11 cases (73.3%) and severe in 4 cases (26.7%). It could be concluded that hookworm anemia was characterized by iron deficiency anemia with eosinophilia, high serum total IgE level, hypoalbuminemia and moderate to severe hookworm infection.
在巴厘岛的贾加帕蒂村开展了一项横断面研究，以评估成年人群中钩虫性贫血的一些特征。钩虫性贫血被定义为重度感染个体（每克粪便虫卵数>EPG>2000）中的缺铁性贫血。采用了世界卫生组织的贫血标准和赫伯格的缺铁标准。在本研究中，454份总样本中有15例钩虫性贫血（3.3%），或123例缺铁性贫血中有15例（12.2%）。年龄在16至69岁之间，男女比例为1:2.8。发现12例有贫血症状和体征，1例为典型钩虫性贫血，2例无症状。血红蛋白水平为4.5至12.9克/分升，其中12例（80.0%）被归类为轻度贫血，2例（13.3%）为中度贫血，1例为重度贫血。血清铁平均水平为39.6毫克/分升，转铁蛋白饱和度平均为11.1%，血清铁蛋白平均水平为9.6纳克/分升。9例（60.0%）发现有低白蛋白血症，8例（53.3%）有嗜酸性粒细胞增多，5例（38.5%）血清叶酸水平低。除1例外，所有病例血清总IgE水平均高，血清总IgE平均水平为3739单位/毫升。11例（73.3%）钩虫感染强度为中度，4例（26.7%）为重度。可以得出结论，钩虫性贫血的特征是伴有嗜酸性粒细胞增多、血清总IgE水平高、低白蛋白血症以及中度至重度钩虫感染的缺铁性贫血。
