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[通过图像分析检测子宫内膜浆液性乳头状腺癌的定量DNA参数——单病例分析]

[Examination by image analysis for determining quantitative DNA parameters of serous papillary adenocarcinoma of the endometrium--a single case analysis].

作者信息

Köhler U, Horn L G, Naumann G, Nenning H, Bilek K

机构信息

Universitätsfrauenklinik, Universität Leipzig.

出版信息

Zentralbl Gynakol. 1995;117(4):213-6.

PMID:7778358
Abstract

Serous-papillary adenocarcinoma of the endometrium are rare tumors. We describe DNA-parameters of such a tumor. Imprint-cytologies were taken from 6 different tumor sites (myometrial invasion and 5 additional tumor localizations) and subjected to image-cytophotometry in order to determine their DNA-parameters. All histograms showed an aneuploid DNA-pattern. The DNA-malignancy grade (DNA-MG) was 2.21 +/- 0.11 on median and the 5c exceeding rate (5c ER) was 15.37 +/- 4.17 on median. These results and the slight variability of DNA-pattern at the reported serous-papillary adenocarcinoma support the hypothesis of an own entity of this tumor. Additionally, the high values of DNA-MG and 5c ER confirm the well known aggressive behavior of this tumor entity.

摘要

子宫内膜浆液性乳头状腺癌是罕见肿瘤。我们描述了这样一种肿瘤的DNA参数。从6个不同肿瘤部位(肌层浸润和另外5个肿瘤定位处)获取印片细胞学样本,并进行图像细胞光度测定以确定其DNA参数。所有直方图均显示非整倍体DNA模式。DNA恶性度分级(DNA-MG)中位数为2.21±0.11,5c超率(5c ER)中位数为15.37±4.17。这些结果以及所报道的浆液性乳头状腺癌DNA模式的轻微变异性支持了该肿瘤具有自身实体的假说。此外,DNA-MG和5c ER的高值证实了该肿瘤实体众所周知的侵袭性行为。

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