Boisier P, Ravaoalimalala V A, Serieye J, Roux J, Esterre P
Institut Pasteur de Madagascar.
Arch Inst Pasteur Madagascar. 1994;61(1):43-8.
The examination of 544 inhabitants (93.2% of the whole population) of a village in the middle west of Madagascar, where Schistosoma mansoni is hyperendemic and where no previous antischistosomal treatment had been delivered at a community level, showed a prevalence rate of 61.8%. The highest prevalences and the most intense infections were observed in the 10-24 age group. The egg count decreases dramatically from the age of 25. A highly significant relationship was found between recent histories of bloody diarrhoea and S. mansoni eggs excretion. Clinical examination showed a high frequency of splenomegalies (62.2% > or = stade 2 Hackett), with two modes: one in the 10-14 age group and the other in the 35-39 age group. The respective liability of S. mansoni and malaria remain to be clarified. Side effects after treatment of the entire population with praziquantel were observed in 27.2% of treated individuals. Side effects occurred mainly in infected people. A highly significant relationship was found between intensity of infection and frequency of these side effects which are essentially mild and disappear in the 24 hours.
对马达加斯加中西部一个村庄的544名居民（占全村总人口的93.2%）进行了检查，该地区曼氏血吸虫病高度流行，此前从未在社区层面开展过抗血吸虫治疗，检查结果显示患病率为61.8%。在10至24岁年龄组中观察到最高的患病率和最严重的感染情况。从25岁起，虫卵计数急剧下降。在近期有血性腹泻病史与曼氏血吸虫虫卵排泄之间发现了高度显著的关系。临床检查显示脾肿大的发生率很高（62.2%≥哈克特2期），有两个高峰：一个在10至14岁年龄组，另一个在35至39岁年龄组。曼氏血吸虫病和疟疾各自的影响仍有待阐明。用吡喹酮治疗全村人口后，27.2%的治疗个体出现了副作用。副作用主要发生在感染者身上。在感染强度与这些副作用的发生频率之间发现了高度显著的关系，这些副作用基本上较轻，在24小时内消失。
