Armitage R, Trivedi M, Rush A J
University of Texas Southwestern Medical Center at Dallas 75235-9070, USA.
Neuropsychopharmacology. 1995 Apr;12(2):159-65. doi: 10.1016/0893-133X(94)00075-B.
The effects of fluoxetine on automated measures of electrooculographic (EOG) and electromyographic (EMG) activity were evaluated in 41 patients with nonpsychotic, major depressive disorder. Sleep EEG evaluations were conducted at baseline, while patients were symptomatic and unmedicated, and following four to five weeks of treatment with fluoxetine (20 mg). The number of eye movements (> 75 microV) and the amplitude of EOG and EMG activity increased significantly on treatment in REM, stages 1, 2, and slow-wave sleep. All patients showed EOG and EMG abnormalities in at least one stage of sleep. Thirty-four percent of patients showed increased EOG and EMG activity on treatment in every sleep stage. It is suggested that fluoxetine-induced oculomotor abnormalities are likely to be the result of increased availability of serotonin and secondary dopaminergic effects.
在41例非精神病性重度抑郁症患者中评估了氟西汀对眼动电图（EOG）和肌电图（EMG）活动自动测量指标的影响。在基线时进行睡眠脑电图评估，此时患者有症状且未用药，以及在使用氟西汀（20毫克）治疗四至五周后进行评估。在快速眼动睡眠、第1、2阶段和慢波睡眠中，治疗后眼动次数（>75微伏）以及EOG和EMG活动的幅度显著增加。所有患者在至少一个睡眠阶段均表现出EOG和EMG异常。34%的患者在每个睡眠阶段治疗后EOG和EMG活动均增加。提示氟西汀引起的动眼异常可能是血清素可用性增加及继发多巴胺能效应的结果。
