Dorsey C M, Lukas S E, Cunningham S L
Sleep Disorders Center, McLean Hospital, Harvard Medical School, Belmont, MA 02178, USA.
Neuropsychopharmacology. 1996 Jun;14(6):437-42. doi: 10.1016/0893-133X(95)00148-7.
Abnormal polysomnographic (PSG) features, most notably increased electromyographic (EMG) tone and eye movements during non-REM sleep have been observed during sleep in fluoxetine-treated depressed patients. However, the relationship between these PSG features and sleep disruption is unclear. Nine depressed patients treated with 10 to 80 mg of fluoxetine and six unmedicated, depressed patients were studied polysomnographically on two consecutive nights during which sleep parameters, transient arousals, and eye movements were measured. The fluoxetine group experienced a lower-average sleep efficiency index (SEI) and significantly more eye movements and arousals during non-REM sleep than the control group. Eye movement and arousal counts were significantly correlated. In addition, clinically significant periodic limb movement disorder (PLMD) was observed in 44% of the fluoxetine-treated group versus none of the control group. We conclude that a higher incidence of PLMD and frequent transient arousals associated with eye movements may be responsible in part for the complaint of insomnia made by patients treated with fluoxetine.
在接受氟西汀治疗的抑郁症患者睡眠期间，观察到了异常的多导睡眠图（PSG）特征，最显著的是在非快速眼动睡眠期间肌电图（EMG）张力增加和眼动增多。然而，这些PSG特征与睡眠中断之间的关系尚不清楚。对9名接受10至80毫克氟西汀治疗的抑郁症患者和6名未接受药物治疗的抑郁症患者进行了连续两晚的多导睡眠图研究，在此期间测量了睡眠参数、短暂觉醒和眼动。与对照组相比，氟西汀组的平均睡眠效率指数（SEI）较低，在非快速眼动睡眠期间的眼动和觉醒明显更多。眼动次数和觉醒次数显著相关。此外，44%接受氟西汀治疗的患者出现了具有临床意义的周期性肢体运动障碍（PLMD），而对照组无一出现。我们得出结论，PLMD的较高发生率以及与眼动相关的频繁短暂觉醒可能部分导致了接受氟西汀治疗的患者所抱怨的失眠。
