双（乙酸根）氨二氯（环己胺）铂（IV），一种口服活性抗癌药物。
Bis(acetato)amminedichloro(cyclohexylamine)platinum(IV), an orally active anticancer drug.
作者信息
Neidle S, Snook C F, Murrer B A, Barnard C F
机构信息
CRC Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, England.
出版信息
Acta Crystallogr C. 1995 May 15;51 ( Pt 5):822-4. doi: 10.1107/s0108270194013600.
The structure of the anticancer drug bis(acetato)-amminedichloro(cyclohexylamine)platinum(IV), [PtCl2-(C2H3O2)2(C6H13N)(NH3)], is reported. The acetato groups are axial to the square plane composed of the chlorine and amine substituents. The cyclohexane ring may sterically hinder one of the acetato groups for metabolic attack. The amine groups are hydrogen bonded to the carbonyl O atoms of the acetato groups.
报道了抗癌药物双（乙酸根）-氨二氯（环己胺）铂（IV），即[PtCl2-(C2H3O2)2(C6H13N)(NH3)]的结构。乙酸根基团位于由氯和胺取代基组成的平面正方形的轴向位置。环己烷环可能在空间上阻碍其中一个乙酸根基团遭受代谢攻击。胺基团通过氢键与乙酸根基团的羰基O原子相连。
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