Blair C, Ramey C T, Hardin J M
Civitan International Research Center, University of Alabama at Birmingham 35294-0021, USA.
Am J Ment Retard. 1995 Mar;99(5):542-54.
The Infant Health and Development Program was an eight-site randomized controlled trial of comprehensive early intervention for low birthweight, premature infants during the first 3 years of life in which intellectual development was an outcome of major importance. At 24 and 36 months, but not at 12 months, higher Mental Development Index and IQ were associated with higher levels of participation in the intervention. In a longitudinal analysis of these data, we found that the intellectual development of children in the intervention group was associated with each of the three intervention modalities (the number of home visits received, days attended at child centers, and the number of parent meetings attended) but not with children's background characteristics (i.e., maternal education, birthweight). We suggest that these findings represent a dose-response relation between intervention and outcome.
婴儿健康与发展项目是一项在八个地点开展的随机对照试验，针对低体重早产儿在其生命的头三年进行全面早期干预，其中智力发展是一个至关重要的结果。在24个月和36个月时，但不是在12个月时，较高的心理发展指数和智商与更高水平的干预参与度相关。在对这些数据的纵向分析中，我们发现干预组儿童的智力发展与三种干预方式中的每一种（接受家访的次数、在儿童中心出勤的天数以及参加家长会议的次数）相关，但与儿童的背景特征（即母亲教育程度、出生体重）无关。我们认为这些发现代表了干预与结果之间的剂量反应关系。
