Santos M C, Rodrigues H, Vasconcelos S, Andrade V, Lança M J, Crespo A M
Departamento de Química, Faculdade de Ciências de Lisboa, Portugal.
Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):257-61. doi: 10.1007/BF02790125.
Two age groups, 3 and 15 mo, were used to investigate whether age-associated changes in some parameters related to lipid peroxidation occur in the liver of male Wistar rats and to observe possible effects of dietary selenium supplementation (0.25 and 0.50 ppm) for 12 mo on the same parameters. At these experimental conditions, the most important observation was that peroxidation did not change by aging, at least until 15 mo of age. In addition, the activity of Se-dependent glutathione peroxidase (GSH-Px, EC 1.11.1.9) was higher in the liver of the older animals. It is suggested that the enzyme could have a role in the unchanged hepatic peroxidation observed in aged male rats. On the other hand, an effect of dietary selenium supplementation on those parameters was not observed, probably because the selenium levels were still at an adequate plateau.
选用3月龄和15月龄两个年龄组的雄性Wistar大鼠，以研究与脂质过氧化相关的某些参数是否会随年龄增长而在肝脏中发生变化，并观察为期12个月的膳食补充硒（0.25 ppm和0.50 ppm）对相同参数可能产生的影响。在这些实验条件下，最重要的观察结果是，至少在15月龄之前，过氧化作用不会随年龄增长而变化。此外，老年动物肝脏中硒依赖性谷胱甘肽过氧化物酶（GSH-Px，EC 1.11.1.9）的活性较高。这表明该酶可能在老年雄性大鼠肝脏过氧化作用未发生变化中发挥作用。另一方面，未观察到膳食补充硒对这些参数有影响，可能是因为硒水平仍处于充足的稳定状态。
