Lip G, Beevers M, Churchill D, Beevers D G
University Department of Medicine, City Hospital, Birmingham.
Br J Clin Pract. 1995 Mar-Apr;49(2):61-4.
Despite the benefits of hormone replacement therapy (HRT) in relieving menopausal symptoms, there continues to be anxiety about its use in women who also have hypertension. To examine clinical practice in relation to HRT, especially in patients with hypertension, and to canvass opinions on potential or perceived side-effects, the authors conducted a postal survey of HRT prescribing habits among 285 GPs, physicians and obstetricians in the West Midlands. The overall response rate to the questionnaire was 191 (66.3%): 61 clinicians reported that they would not prescribe HRT in women whose hypertension was difficult to control, but only 3 would withhold treatment if blood pressure was well controlled; 9% of physicians and 13% of gynaecologists did not routinely measure blood pressure before starting HRT or monitor BP at follow-up (24% and 10% respectively). A proportion of GPs (20%), physicians (21%) and gynaecologists (9%) reported that in their opinion HRT raised blood pressure, and a minority in each group considered that HRT increased the risk of venous thrombosis, stroke and myocardial infarction. This study demonstrates differences among GPs, physicians and gynaecologists in the use of HRT in menopausal women with hypertension, the authors suggest that, in view of data from studies of the effects of HRT on blood pressure and the possible reduction of cardiovascular disease, these clinicians can be reassured and hypertensive women need not be denied the benefits of HRT, as long as there is careful monitoring.
尽管激素替代疗法(HRT)在缓解更年期症状方面有诸多益处,但对于患有高血压的女性使用该疗法仍存在担忧。为了研究与HRT相关的临床实践,尤其是高血压患者的情况,并征求关于潜在或已察觉到的副作用的意见,作者对西米德兰兹郡的285名全科医生、内科医生和产科医生进行了一项关于HRT处方习惯的邮寄调查。问卷的总体回复率为191份(66.3%):61名临床医生表示,他们不会给难以控制高血压的女性开HRT,但如果血压控制良好,只有3人会拒绝治疗;9%的内科医生和13%的妇科医生在开始HRT前没有常规测量血压,或在随访时没有监测血压(分别为24%和10%)。一定比例的全科医生(20%)、内科医生(21%)和妇科医生(9%)报告称,在他们看来HRT会升高血压,且每组中都有少数人认为HRT会增加静脉血栓形成、中风和心肌梗死的风险。这项研究表明,全科医生、内科医生和妇科医生在对患有高血压的更年期女性使用HRT方面存在差异,作者建议,鉴于HRT对血压影响的研究数据以及心血管疾病可能的减少,这些临床医生可以放心,只要进行仔细监测,高血压女性不必被剥夺HRT的益处。