实验性实体瘤中微区域红细胞通量的时间异质性。
Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours.
作者信息
Chaplin D J, Hill S A
机构信息
Tumour Microcirculation Group, Cancer Research Campaign Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK.
出版信息
Br J Cancer. 1995 Jun;71(6):1210-3. doi: 10.1038/bjc.1995.235.
Abstract
Using a multichannel laser Doppler system equipped with custom-developed microprobes, we have evaluated real-time fluctuations in microregional blood flow in two experimental murine tumour systems. The results show that in both the sarcoma F and the carcinoma NT over 50% of the microregions evaluated show a fluctuation in red blood cell flux by at least a factor of 2 over a 60 min time period. Approximately 20% of the regions monitored demonstrated a change in flow by a factor of 5 or more. Within the 1 h monitoring period, approximately 20% of the changes were reversed (SaF, 21%; CaNT, 19%). The duration of change for these regions ranged from 6 to 45 min. Similar temporal fluctuations in flow were seen in anaesthetised and unanaesthetised animals, indicating that artifacts due to probe movement were minimal. These findings clearly demonstrate that fluctuations in microregional erythrocyte flux are a common feature of the experimental tumours studied.
摘要
我们使用配备了定制微探头的多通道激光多普勒系统，评估了两种实验性小鼠肿瘤系统中微区血流的实时波动情况。结果显示，在肉瘤F和癌NT中，超过50%的评估微区在60分钟时间段内红细胞通量波动至少2倍。约20%的监测区域血流变化达5倍或更高。在1小时监测期内，约20%的变化出现逆转（肉瘤F为21%；癌NT为19%）。这些区域的变化持续时间为6至45分钟。在麻醉和未麻醉的动物中均观察到类似的血流时间波动，表明探头移动引起的伪影极小。这些发现清楚地表明，微区红细胞通量波动是所研究实验性肿瘤的一个共同特征。
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