O'Hanlon D M, Kerin M J, Kent P, Maher D, Grimes H, Given H F
Department of Surgery, University College Hospital, Galway, Ireland.
Br J Cancer. 1995 Jun;71(6):1288-91. doi: 10.1038/bjc.1995.249.
In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.
在这项对500例乳腺癌患者的研究中，我们前瞻性地评估了术前CA 15 - 3作为疾病负荷标志物在7年期间的作用。就诊时的CA 15 - 3水平与疾病分期、肿瘤大小、淋巴结状态、转移情况以及肿瘤内淋巴细胞浸润相关。尽管血清水平>40 U/ml对晚期疾病的存在具有83%的阳性预测价值，但单独的CA 15 - 3并非独立的预后指标。我们建议在原发性乳腺癌的术前评估中常规使用该标志物。
