Ciofu C, Gherghina I, Craiu I, Anca I, Aboussaad O
Institute for Assistance of Mother and Children Care, Bucharest, Romania.
Rom J Neurol Psychiatry. 1994 Oct-Dec;32(4):253-8.
A previously healthy 9-month-old girl, obese (12,500 gm) with sudden onset of hyperthermia (40 degrees C), generalized tonic-clonic seizures, followed by focal seizures, drowsiness, left facial nerve palsy, left lagophthalmos and mydriasis is presented. CT-scan and MRI suggested temporal-parietal infarction due to Sylvian artery occlusion in a 9-month-old infant with familial hypercholesterolemia (type 2 A dyslipidemia). The possibility of a cerebral abscess or herpetic encephalitis was considered. Negative clinic and serologic results excluded this diagnosis. The management of the symptomatology was made with parenteral antibiotics, anticonvulsive and antioedematous cerebral therapy. Favourable evolution with residual left hemiparesis after 30 days, when the child was discharged. CT-scan reevaluation (after 5 months of evolution) showed a hypodense temporal-parietal area abnormality due to a right ischemic infarction.
本文报告了一名既往健康的9个月大肥胖女童(体重12,500克),突发高热(40摄氏度),出现全身性强直阵挛性癫痫发作,随后出现局灶性癫痫发作、嗜睡、左侧面神经麻痹、左侧眼睑闭合不全和瞳孔散大。CT扫描和MRI提示,一名患有家族性高胆固醇血症(2A型血脂异常)的9个月大婴儿因大脑中动脉闭塞导致颞顶叶梗死。曾考虑过脑脓肿或疱疹性脑炎的可能性。临床和血清学检查结果均为阴性,排除了该诊断。针对症状采用了肠外抗生素、抗惊厥和抗脑水肿的脑部治疗。30天后患儿出院时病情好转,但仍遗留左侧偏瘫。(病情进展5个月后)CT扫描复查显示,右侧缺血性梗死导致颞顶叶区域出现低密度异常。