Sawyer S M, Rosier M J, Phelan P D, Bowes G
Department of Thoracic Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.
J Adolesc Health. 1995 Mar;16(3):204-8. doi: 10.1016/1054-139X(94)00071-L.
The changing expectations, therapies and outcomes for young people with cystic fibrosis (CF) necessitate a re-evaluation of the impact of this chronic illness on adolescent development. The aim of this study was to assess the psychological well-being and adjustment of contemporary adolescents with CF.
Forty-nine adolescents with CF (24 males, 25 females) aged 14-18 years were enrolled from the Royal Children's Hospital CF Clinic, Melbourne, Australia. The Offer Self-Image Questionnaire was administered to participating subjects whose growth and pubertal developmental and pulmonary function was assessed.
The mean (SD) FEV1% was 82 (21), and mean (SD) National Institute of Health clinical score was 81 (12). There were no significant differences between males and females in pulmonary function or clinical scores, but growth and pubertal development were delayed in both sexes. Females, but not males, with CF were less well-adjusted than their healthy peers. Two-way analysis of variance was performed and showed significant sex differences in sub-scales of the Offer questionnaire numbers I, II, III, VI, VIII, IX, as well as in the total score. Age was significant only for scales II and VIII, and only scale II displayed an interaction between sex and age.
This study suggests that adjustment and self-esteem are less than ideal in young people with CF, especially females.
囊性纤维化（CF）青少年患者的期望、治疗方法及治疗结果不断变化，这使得有必要重新评估这种慢性病对青少年发育的影响。本研究的目的是评估当代CF青少年的心理健康状况和适应能力。
从澳大利亚墨尔本皇家儿童医院CF诊所招募了49名年龄在14 - 18岁的CF青少年（24名男性，25名女性）。对参与研究的受试者进行了奥弗自我形象问卷测试，并评估了他们的生长发育、青春期发育及肺功能。
平均（标准差）第一秒用力呼气容积（FEV1）百分比为82（21），平均（标准差）美国国立卫生研究院临床评分为81（12）。男性和女性在肺功能或临床评分方面无显著差异，但两性的生长发育和青春期发育均延迟。患有CF的女性比健康同龄人适应能力更差，而男性则不然。进行了双向方差分析，结果显示奥弗问卷的I、II、III、VI、VIII、IX子量表以及总分存在显著的性别差异。年龄仅在量表II和VIII上具有显著性，且只有量表II显示出性别和年龄之间的交互作用。
本研究表明，CF青少年，尤其是女性，其适应能力和自尊水平不太理想。
