Munakata M, Imai Y, Mizunashi K, Hashimoto J, Sekino H, Furukawa Y, Abe K
Second Department of Internal Medicine, Tohoku University, School of Medicine, Sendai, Japan.
Clin Auton Res. 1995 Feb;5(1):5-11. doi: 10.1007/BF01845492.
This study was designed to determine whether calcium contributes to the regulation of rhythmic oscillations in blood pressure. Six normal subjects received sequential 1-h infusions of calcium gluconate (1.5, 3.0 and 4.5 mg calcium/kg/h) during continuous blood pressure (Finapres) monitoring. The plasma ionized calcium ([Ca2+]) concentration increased from 4.6 +/- 0.07 mg/dl to 5.97 +/- 0.20 mg/dl (p < 0.01) with infusion. The mid-frequency (0.07-0.14 Hz, Mayer wave) power spectrum of diastolic blood pressure was depressed slightly following the first dose but increased significantly following the final dose (p < 0.05). The high-frequency (0.15-0.40 Hz) power spectrum of systolic blood pressure decreased following the first dose (p < 0.05) and subsequently remained low. The low-frequency (0.02-0.6 Hz) power spectrum was not affected. These results demonstrate that graded hypercalcaemia affects blood pressure oscillations in man. Our data suggest that the amplitude of the Mayer wave, a clinical marker of sympathetic vascular tone, is modulated in part by calcium.
本研究旨在确定钙是否有助于调节血压的节律性振荡。在连续监测血压（Finapres）期间，六名正常受试者接受了葡萄糖酸钙的连续1小时输注（1.5、3.0和4.5毫克钙/千克/小时）。输注期间，血浆离子钙（[Ca2+]）浓度从4.6±0.07毫克/分升增加到5.97±0.20毫克/分升（p<0.01）。舒张压的中频（0.07 - 0.14赫兹，迈尔波）功率谱在首次给药后略有下降，但在最后一次给药后显著增加（p<0.05）。收缩压的高频（0.15 - 0.40赫兹）功率谱在首次给药后下降（p<0.05），随后保持较低水平。低频（0.02 - 0.6赫兹）功率谱未受影响。这些结果表明，分级高钙血症会影响人体的血压振荡。我们的数据表明，作为交感神经血管张力临床标志物的迈尔波振幅部分受钙调节。
