18F标记的HFA-134a的合成及体内处置研究。

Synthesis and in vivo disposition studies of 18F-labeled HFA-134a.

作者信息

Finch J R, Banks W R, Hwang D R, Satter M R, Ezzidene B, Mantil J C, Digenis G A

机构信息

Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.

出版信息

Appl Radiat Isot. 1995 Apr;46(4):241-8. doi: 10.1016/0969-8043(94)00129-n.

DOI:10.1016/0969-8043(94)00129-n

PMID:7780376

Abstract

A rapid synthesis of the chlorofluorocarbon replacement compound 1,1,1,2-tetrafluoroethane (HFA-134a) was identified and utilized to prepare 99+% radiochemically pure [18F]HFA-134a in 20-35% radiochemical yield. Four rats were then exposed to no-carrier-added (NCA) [18F]HFA-134a, and monitored via coincidence detection. Following withdrawal of the test atmosphere of [18F]HFA-134a, the mean half-life of [18F]HFA-134a in four rats was determined to be 7.8 +/- 1.5 min following a 10 s exposure and 8.1 +/- 1.7 minutes following a 10 min exposure.

摘要

已确定并利用一种快速合成氯氟烃替代化合物1,1,1,2 - 四氟乙烷（HFA - 134a）的方法，以20 - 35%的放射化学产率制备出放射化学纯度大于99%的[¹⁸F]HFA - 134a。随后，对四只大鼠暴露于无载体添加（NCA）的[¹⁸F]HFA - 134a，并通过符合探测进行监测。在撤离[¹⁸F]HFA - 134a的测试气氛后，测定出四只大鼠体内[¹⁸F]HFA - 134a在10秒暴露后的平均半衰期为7.8±1.5分钟，在10分钟暴露后的平均半衰期为8.1±1.7分钟。