Chanana G D, Sheth B B
Department of Pharmaceutics, University of Tennessee, Memphis, USA.
PDA J Pharm Sci Technol. 1995 Mar-Apr;49(2):71-6.
The objective of this study was to investigate the effect of the concentration of surfactant and oil on particle size reduction and stability of oil-in-water emulsion formulations containing polyhydroxy alcohols. Emulsions were prepared using an emulsifier system consisting of Tween 80 and Span 80 with 5%, 10%, 15% and 20% soybean oil and containing 50% w/w of either propylene glycol (PG) or glycerol (GLY) in the external phase. At each oil concentration, four emulsions were formulated with increasing surfactant concentration to provide emulsions with surfactant to oil (S/O) ratios of 0.1, 0.2, 0.3 and 0.4. Three parameters were evaluated, particle size reduction, particle size stability upon dilution, and viscosity. It was found that increase in S/O ratio resulted in substantial decrease in particle size in all cases. But there was a difference in the particle size reduction pattern between PG and GLY. Increase in oil concentration at the same S/O ratio caused particle size reduction for emulsions with PG but not for emulsions with GLY. The reduction in particle size was also greater for emulsions containing PG. Further, particle size of emulsions containing PG was found to be stable over 24 hours after dilution. However, a slight increase in particle size was observed in emulsions containing GLY. It was also found that the viscosity of emulsions increased with an increase S/O ratio as well as the concentration of the oil.
本研究的目的是调查表面活性剂和油的浓度对含有多元醇的水包油乳液制剂粒径减小和稳定性的影响。使用由吐温80和司盘80组成的乳化剂体系制备乳液，其中大豆油含量分别为5%、10%、15%和20%，外相中含有50%（w/w）的丙二醇（PG）或甘油（GLY）。在每个油浓度下，配制四种乳液，随着表面活性剂浓度增加，使乳液的表面活性剂与油（S/O）比分别为0.1、0.2、0.3和0.4。评估了三个参数，即粒径减小、稀释后粒径稳定性和粘度。结果发现，在所有情况下，S/O比的增加都会导致粒径大幅减小。但PG和GLY在粒径减小模式上存在差异。在相同S/O比下，油浓度增加会使含PG的乳液粒径减小，但含GLY的乳液粒径不变。含PG的乳液粒径减小幅度也更大。此外，发现含PG的乳液在稀释后24小时内粒径稳定。然而，含GLY的乳液粒径略有增加。还发现乳液的粘度随着S/O比以及油浓度的增加而增加。
