Chanana G D, Sheth B B
Department of Pharmaceutics, University of Tennessee, Memphis.
J Parenter Sci Technol. 1993 May-Jun;47(3):130-4.
The objective of this study was to characterize the effect on particle size and stability of oil-in-water emulsion formulations caused by the addition of polyhydroxy alcohols. Stable soybean oil and hexadecane emulsions were prepared containing increasing amounts of propylene glycol (PG) and glycerol (GLY). A nonionic emulsifier system consisting of Tween 80 and Span 80 was used to achieve optimal stability. Particle size was found to decrease as the level of PG or GLY increased. A three-fold particle size reduction was obtained at a PG level of 40% w/w and at a GLY level of 70% w/w. The particle size of soybean oil emulsions decreased from about 4.8 microns to about 1.7 microns. The particle size of hexadecane emulsions decreased from about 2.7 microns to less than 1 micron. The increase in emulsion viscosity was found to be proportional to the amount of polyhydroxy alcohols added to the formulation. The particle size and creaming stability of the emulsions were found to improve with increasing PG or GLY concentration.
本研究的目的是表征添加多羟基醇对水包油乳液制剂的粒径和稳定性的影响。制备了含有递增含量丙二醇（PG）和甘油（GLY）的稳定大豆油乳液和十六烷乳液。使用由吐温80和司盘80组成的非离子乳化剂体系以实现最佳稳定性。发现随着PG或GLY水平的增加，粒径减小。在PG水平为40% w/w和GLY水平为70% w/w时，粒径降低了三倍。大豆油乳液的粒径从约4.8微米降至约1.7微米。十六烷乳液的粒径从约2.7微米降至小于1微米。发现乳液粘度的增加与添加到制剂中的多羟基醇的量成比例。发现随着PG或GLY浓度的增加，乳液的粒径和乳析稳定性得到改善。
