Kase F, Klír P, Pospísil J, Poucková P
Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(1):1-19.
The discovery of factor XII (Hageman factor), the attempts of characterizing it, the knowledge of its presence of absence in the various vertebrate classes are represented in a survey and recent opinions of molecular biology about its structure and composition are discussed. The effect of the activating substances for transferring the Hageman factor into its active form are represented with the role of the pre-kallikrein (Fletcher factor) and of the highly molecular kininogen (Fitzgerald factor) being referred to. Furthermore, the following systems influenced by factor XII are dealt with: 1. The endogenous and exogenous activating system of blood clotting and possible reasons for lower bleedings with factor XII deficiency. 2. Role of the Hageman factor in activating fibrinolysis. 3. Influence on the liberation of kinin. 4. Correlations towards the complement system. 5. Possible inhibitory effect of platelet aggregation. Finally the close connection of all these systems is referred to and the necessity of considering these complicated events in a complex way is stressed.
本文综述了凝血因子 XII（哈格曼因子）的发现过程、对其进行特性描述的尝试，以及不同脊椎动物类群中该因子存在与否的相关知识，并讨论了分子生物学对其结构和组成的最新观点。文中阐述了将哈格曼因子转化为活性形式的激活物质的作用，同时提及了前激肽释放酶（弗莱彻因子）和高分子量激肽原（菲茨杰拉德因子）的作用。此外，还探讨了受凝血因子 XII 影响的以下系统：1. 内源性和外源性凝血激活系统以及凝血因子 XII 缺乏时出血减少的可能原因。2. 哈格曼因子在激活纤溶中的作用。3. 对激肽释放的影响。4. 与补体系统的相关性。5. 对血小板聚集可能的抑制作用。最后，本文指出了所有这些系统之间的紧密联系，并强调了以综合方式考虑这些复杂事件的必要性。
