Complement components are activated by immunologic and non-immunologic mechanisms through various plasma protein systems such as immunoglobulins, properdin, plasmin, thrombin and Hageman factor. The activation of Hageman factor, followed by complement cleavage leading to liberation of various chemical mediators, can be initiated by exposure of negatively charged tissue components due to trauma and infection.
补体成分通过各种血浆蛋白系统（如免疫球蛋白、备解素、纤溶酶、凝血酶和哈格曼因子）的免疫和非免疫机制被激活。哈格曼因子的激活，随后补体裂解导致各种化学介质的释放，可由创伤和感染引起的带负电荷的组织成分暴露引发。
