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溃疡性结肠炎的管理

The management of ulcerative colitis.

作者信息

Watkinson G

出版信息

Practitioner. 1976 Jun;216(1296):642-8.

PMID:7781
Abstract

The modern medical and surgical treatment of ulcerative colitis has been detailed. Whilst improvements in medical management have been few in the past decade there have been advances in dietary management and in the use of new drugs such as azathioprine and disodium cromoglycate which are currently being evaluated. Sulphasalazine remains a valuable drug in treating attacks of the disease and in preventing relapses, and its mode of action is now better understood. Steroid therapy, used orally, parenterally or topically, is of value in managing acute colitic attacks. Surgery is often required and total proctocolectomy with ileostomy remains the operation of choice. Colectomy with ileorectal anastomosis still remains a controversial operation but has its enthusiastic advocates. The interesting a new operation of proctocolectomy, with the establishment of an ileal bladder and continent ileostomy, is being assessed in Sweden and in a few centres in Britain and America.

摘要

溃疡性结肠炎的现代医学和外科治疗方法已详细阐述。虽然在过去十年中,药物治疗方面进展寥寥,但在饮食管理以及诸如硫唑嘌呤和色甘酸钠等新药的使用上取得了进展,目前这些药物正在接受评估。柳氮磺胺吡啶在治疗该疾病发作和预防复发方面仍然是一种有价值的药物,其作用方式现在也得到了更好的理解。口服、胃肠外给药或局部使用的类固醇疗法,在管理急性结肠炎发作方面具有价值。通常需要进行手术,全直肠结肠切除术加回肠造口术仍然是首选手术。结肠切除术加回肠直肠吻合术仍然是一个有争议的手术,但也有热心的支持者。瑞典以及英美一些中心正在评估一种有趣的新手术——全直肠结肠切除术,同时建立回肠膀胱和可控回肠造口术。

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