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一名患有活动性克罗恩病的产后患者发生严重血栓性并发症,导致脊髓缺血性损伤。

Severe thrombotic complications in a postpartum patient with active Crohn's disease resulting in ischemic spinal cord injury.

作者信息

Slot W B, van Kasteel V, Coerkamp E G, Seelen P J, van der Werf S D

机构信息

Department of Medicine, Westeinde Hospital, The Hague, The Netherlands.

出版信息

Dig Dis Sci. 1995 Jun;40(6):1395-9. doi: 10.1007/BF02065558.

DOI:10.1007/BF02065558
PMID:7781467
Abstract

This report describes a 33-year-old female patient who presented with severe neurological symptoms and signs during postpartum relapse of Crohn's ileocolitis. The cause of the neurological deficit was extensive major vessel thrombosis resulting in spinal cord ischemia. Etiologic factors involved in this exceptional thrombotic state are discussed with emphasis on the relationship between low levels of folic acid, homocysteine metabolism, and coagulation.

摘要

本报告描述了一名33岁女性患者,她在克罗恩病回结肠炎症产后复发期间出现了严重的神经症状和体征。神经功能缺损的原因是广泛的大血管血栓形成导致脊髓缺血。本文讨论了这种特殊血栓形成状态所涉及的病因学因素,重点是低叶酸水平、同型半胱氨酸代谢和凝血之间的关系。

相似文献

1
Severe thrombotic complications in a postpartum patient with active Crohn's disease resulting in ischemic spinal cord injury.一名患有活动性克罗恩病的产后患者发生严重血栓性并发症,导致脊髓缺血性损伤。
Dig Dis Sci. 1995 Jun;40(6):1395-9. doi: 10.1007/BF02065558.
2
[Acute ischemia of the lower extremity in an adolescent with Crohn disease].
Vasa. 1992;21(2):216-8.
3
Postpartum thrombosis of the superior mesenteric artery after vaginal delivery.阴道分娩后肠系膜上动脉的产后血栓形成
Obstet Gynecol. 2008 Feb;111(2 Pt 2):535-7. doi: 10.1097/01.AOG.0000284629.65095.3a.
4
Portal vein thrombosis and multiple liver abscesses in Crohn's disease--an example for successful conservative treatment.克罗恩病并发门静脉血栓形成和多发性肝脓肿——成功保守治疗的一例
Z Gastroenterol. 1997 Aug;35(8):627-30.
5
Arterial thrombosis in Crohn's disease.克罗恩病中的动脉血栓形成。
Med J Aust. 1988 Nov 21;149(10):559-60. doi: 10.5694/j.1326-5377.1988.tb120770.x.
6
[Arterial thrombotic complications in Crohn's disease].
Gastroenterol Clin Biol. 1990;14(3):278-82.
7
Perianal Crohn's disease and pregnancy: role of the mode of delivery.肛周克罗恩病与妊娠:分娩方式的作用
Am J Gastroenterol. 1999 Nov;94(11):3274-8. doi: 10.1111/j.1572-0241.1999.01537.x.
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Postpartum cerebral angiopathy: atypical features and treatment with intracranial balloon angioplasty.
Neuroradiology. 2004 Dec;46(12):1022-6. doi: 10.1007/s00234-003-1129-3. Epub 2004 Nov 27.
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Recurrent left ventricular thrombus in Crohn's disease: a rare presentation.克罗恩病患者复发性左心室血栓形成:一种罕见的表现。
Asian Cardiovasc Thorac Ann. 2014 Jan;22(1):86-8. doi: 10.1177/0218492312467638. Epub 2013 Jul 11.
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Increased levels of homocysteine in patients with Crohn's disease are related to folate levels.克罗恩病患者体内同型半胱氨酸水平升高与叶酸水平有关。
Am J Gastroenterol. 2000 Dec;95(12):3498-502. doi: 10.1111/j.1572-0241.2000.03367.x.

引用本文的文献

1
Hyperhomocysteinemia in ulcerative colitis is related to folate levels.溃疡性结肠炎中的高同型半胱氨酸血症与叶酸水平有关。
World J Gastroenterol. 2005 Oct 14;11(38):6038-42. doi: 10.3748/wjg.v11.i38.6038.
2
Homocysteine, cysteine, and glutathione in human colonic mucosa: elevated levels of homocysteine in patients with inflammatory bowel disease.人结肠黏膜中的同型半胱氨酸、半胱氨酸和谷胱甘肽:炎症性肠病患者同型半胱氨酸水平升高。
Dig Dis Sci. 2003 Oct;48(10):2083-90. doi: 10.1023/a:1026338812708.
3
Neurology and the gastrointestinal system.神经病学与胃肠系统。

本文引用的文献

1
Immunohistochemical study of tissue factor expression in normal intestine and idiopathic inflammatory bowel disease.正常肠道和特发性炎症性肠病中组织因子表达的免疫组织化学研究
J Clin Pathol. 1993 Aug;46(8):703-8. doi: 10.1136/jcp.46.8.703.
2
Homocysteinemia: association of a metabolic disorder with vascular disease and thrombosis.高同型半胱氨酸血症:一种代谢紊乱与血管疾病和血栓形成的关联。
Thromb Res. 1993 Sep 1;71(5):337-59. doi: 10.1016/0049-3848(93)90160-p.
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The natural history of homocystinuria due to cystathionine beta-synthase deficiency.
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由于胱硫醚β-合酶缺乏导致的同型胱氨酸尿症的自然病史。
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Activation of blood coagulation in Crohn's disease. Increased plasma fibrinopeptide A levels and enhanced generation of monocyte tissue factor activity.
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Homocysteinemia due to folate deficiency.叶酸缺乏所致高同型半胱氨酸血症
Metabolism. 1987 May;36(5):458-62. doi: 10.1016/0026-0495(87)90043-6.
6
Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator.同型半胱氨酸诱导的血管内皮细胞激活剂对内源性因子V的激活作用。
J Clin Invest. 1986 Jun;77(6):1909-16. doi: 10.1172/JCI112519.
7
Higher total plasma homocysteine in vitamin B12 deficiency than in heterozygosity for homocystinuria due to cystathionine beta-synthase deficiency.维生素B12缺乏时血浆总同型半胱氨酸水平高于因胱硫醚β合酶缺乏导致的同型胱氨酸尿症杂合子状态时的水平。
Metabolism. 1988 Feb;37(2):175-8. doi: 10.1016/s0026-0495(98)90014-2.
8
Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.采用毛细管气相色谱-质谱联用技术检测钴胺素或叶酸缺乏患者血清中总同型半胱氨酸水平升高。
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Vascular complications of inflammatory bowel disease.
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10
Prothrombotic abnormalities in inflammatory bowel disease.炎症性肠病中的血栓前状态异常。
Dig Dis Sci. 1989 Jul;34(7):1089-93. doi: 10.1007/BF01536380.