Conlan M G, Haire W D, Burnett D A
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68105-1065.
Dig Dis Sci. 1989 Jul;34(7):1089-93. doi: 10.1007/BF01536380.
Inflammatory bowel disease (IBD) is known to be associated with a thrombotic tendency, which is often attributed to thrombocytosis, elevated fibrinogen, or decreased antithrombin III. We prospectively studied eight patients with IBD, seven of whom had little or no disease activity, to determine if they had any laboratory abnormality known to be associated with an increased risk of thrombosis. Abnormalities in fibrinolysis were noted in five patients: four with high plasminogen activator inhibitor levels and one with poor release of tissue plasminogen activator following venous occlusion. Circulating immune complexes were present in the sera of five patients. Fibrinogen was mildly elevated in one patient, and two patients had mild thrombocytosis. Decreased levels of antithrombin III, protein C, or protein S were not observed. There appears to be a high incidence of abnormalities in fibrinolysis in inactive IBD, which may contribute to the high frequency of thrombosis seen in IBD. The presence of circulating immune complexes may contribute to vascular injury and thrombosis.
已知炎症性肠病（IBD）与血栓形成倾向有关，这通常归因于血小板增多、纤维蛋白原升高或抗凝血酶III降低。我们前瞻性地研究了8例IBD患者，其中7例疾病活动轻微或无疾病活动，以确定他们是否存在任何已知与血栓形成风险增加相关的实验室异常。5例患者出现纤维蛋白溶解异常：4例纤溶酶原激活物抑制剂水平高，1例静脉闭塞后组织纤溶酶原激活物释放不佳。5例患者血清中存在循环免疫复合物。1例患者纤维蛋白原轻度升高，2例患者有轻度血小板增多。未观察到抗凝血酶III、蛋白C或蛋白S水平降低。在非活动性IBD中，纤维蛋白溶解异常的发生率似乎很高，这可能是IBD中血栓形成频率高的原因。循环免疫复合物的存在可能导致血管损伤和血栓形成。
