Chikuba N, Akazawa S, Yamaguchi Y, Kawasaki E, Takino H, Yoshimoto M, Ohe N, Yamashita K, Yano A, Nagataki S
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Diabetes Res Clin Pract. 1995 Jan;27(1):31-7. doi: 10.1016/0168-8227(94)01025-u.
HLA-DQA1 and DPB1 alleles were examined in relation to autoimmune thyroid disease (AITD) in the Japanese type 1 diabetic patients. The subjects consisted of 14 type 1 diabetic patients with Graves' disease, 12 patients with Hashimoto's thyroiditis and 32 type 1 diabetic patients without AITD. Comparisons were made with 35 normal controls. Among the type 1 diabetic patients with Graves' disease, the age at onset of diabetes was 31.8 +/- 14.6 years old, which was later than that of those without AITD (P < 0.01). DR9 was increased (57.1% vs. 25.9%, P < 0.05, RR: 3.85, chi 2:4.36) in the patients with Graves' disease. DQA10301 was increased and DQA10103 was decreased in the patients with Graves' disease and those without AITD. HLA-DPB10501 was increased (92.9% vs. 54.3%, P < 0.05, RR: 11.0, chi 2:6.57) in the patients with Graves' disease. These findings suggest the existence of a Graves' complicated subgroup characterized by the increasing association of DPB10501 and late onset of diabetes in Japanese type 1 diabetic patients. There exists a heterogeneity in Japanese type 1 diabetes.
在日本1型糖尿病患者中，对HLA - DQA1和DPB1等位基因与自身免疫性甲状腺疾病（AITD）的关系进行了研究。研究对象包括14例患有格雷夫斯病的1型糖尿病患者、12例桥本甲状腺炎患者以及32例无AITD的1型糖尿病患者。以35名正常对照者作为比较对象。在患有格雷夫斯病的1型糖尿病患者中，糖尿病发病年龄为31.8±14.6岁，晚于无AITD的患者（P<0.01）。格雷夫斯病患者中DR9增加（57.1%对25.9%，P<0.05，相对危险度：3.85，卡方值：4.36）。在患有格雷夫斯病的患者和无AITD的患者中，DQA10301增加而DQA10103减少。格雷夫斯病患者中HLA - DPB10501增加（92.9%对54.3%，P<0.05，相对危险度：11.0，卡方值：6.57）。这些发现提示，在日本1型糖尿病患者中存在一个以DPB10501关联增加和糖尿病发病较晚为特征的格雷夫斯病复杂亚组。日本1型糖尿病存在异质性。
