日本1型（胰岛素依赖型）糖尿病合并自身免疫性甲状腺疾病
Type 1 (insulin-dependent) diabetes mellitus with coexisting autoimmune thyroid disease in Japan.
作者信息
Chikuba N, Akazawa S, Yamaguchi Y, Kawasaki E, Takino H, Takao Y, Maeda Y, Okuno S, Yamamoto H, Yokota A
机构信息
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
出版信息
Intern Med. 1992 Sep;31(9):1076-80. doi: 10.2169/internalmedicine.31.1076.
Type 1 diabetes mellitus is known to be a heterogenous disease which is frequently complicated with other autoimmune thyroid diseases (AITD). The present study was designed to investigate the clinical characteristics and HLA antigens in Japanese Type 1 diabetic patients with AITD. Subjects were 25 Type 1 diabetic patients with AITD (13 Graves' disease and 12 Hashimoto's thyroiditis) and 32 Type 1 diabetic patients without AITD. Compared with Type 1 diabetic patients without AITD, age at onset of diabetes was later and positive ICA persisted much longer in the diabetic patients with AITD. Compared with normal controls, DR9 was increased in the patients with AITD, while DR4 was increased in those without AITD. Type 1 diabetic patients with AITD were characterized by the late onset of diabetes, persistent ICA and increased association with DR9. These results suggest that immunological and genetic heterogeneity may exist within Japanese Type 1 diabetic patients.
1型糖尿病是一种异质性疾病，常并发其他自身免疫性甲状腺疾病（AITD）。本研究旨在调查日本1型糖尿病合并AITD患者的临床特征和HLA抗原。研究对象为25例1型糖尿病合并AITD患者（13例格雷夫斯病和12例桥本甲状腺炎）和32例不合并AITD的1型糖尿病患者。与不合并AITD的1型糖尿病患者相比，合并AITD的糖尿病患者糖尿病发病年龄较晚，ICA阳性持续时间更长。与正常对照组相比，AITD患者中DR9增加，而不合并AITD的患者中DR4增加。1型糖尿病合并AITD患者的特点是糖尿病发病较晚、ICA持续存在且与DR9的关联增加。这些结果表明，日本1型糖尿病患者可能存在免疫和遗传异质性。
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