Healy K, Jovanovic-Peterson L, Peterson C M
Sansum Medical Research Foundation, Santa Barbara, California, USA.
Endocrinol Metab Clin North Am. 1995 Mar;24(1):73-101.
The outcome of pregnancies complicated by pregestational diabetes, both insulin-dependent and non-insulin-dependent, has changed dramatically since the discovery of insulin in the early 1920s. Now, patients with pregestational diabetes can safely undergo a pregnancy and be assured that the infant will be healthy. Unfortunately, a finite risk of problems still may occur, including congenital malformations, spontaneous abortions, and diabetic fetopathy classically manifest as a macrosomic infant. Treatment strategies, although tedious and sometimes onerous, do minimize these risks.
自20世纪20年代初发现胰岛素以来，患有孕前糖尿病（包括胰岛素依赖型和非胰岛素依赖型）的孕妇的妊娠结局发生了巨大变化。现在，孕前糖尿病患者可以安全地怀孕，并确信婴儿会健康。不幸的是，仍然可能出现一定的问题风险，包括先天性畸形、自然流产以及典型表现为巨大儿的糖尿病胎儿病。治疗策略虽然繁琐，有时甚至艰巨，但确实能将这些风险降至最低。
