Krumholz W, Demel C, Jung S, Meuthen G, Knecht J, Hempelmann G
Department of Anaesthesiology and Intensive Care Medicine, Justus-Liebig-University Giessen, Germany.
Eur J Anaesthesiol. 1995 Mar;12(2):141-6.
Polymorphonuclear leucocytes (PMNL) are an essential component of the defence system against invading bacteria. There is evidence that some anaesthetics are able to suppress PMNL functions, promoting, perhaps, perioperative infection. We studied the effects of thiopentone, etomidate, ketamine, and midazolam on the generation of bactericidal agents (superoxide anion, hydrogen peroxide, and myeloperoxidase) by PMNL in vitro. Thiopentone inhibited superoxide anion (P < or = 0.01) as well as hydrogen peroxide production (P < or = 0.001). However, there was no statistically significant effect on myeloperoxidase release. Neither etomidate nor ketamine influenced the PMNL functions tested to any extent. Midazolam suppressed superoxide anion generation (P < or = 0.01) but only if a concentration far beyond clinical relevance was used.
多形核白细胞（PMNL）是抵御入侵细菌的防御系统的重要组成部分。有证据表明，一些麻醉剂能够抑制PMNL的功能，这可能会增加围手术期感染的风险。我们在体外研究了硫喷妥钠、依托咪酯、氯胺酮和咪达唑仑对PMNL产生杀菌物质（超氧阴离子、过氧化氢和髓过氧化物酶）的影响。硫喷妥钠抑制超氧阴离子的产生（P≤0.01）以及过氧化氢的产生（P≤0.001）。然而，对髓过氧化物酶的释放没有统计学上的显著影响。依托咪酯和氯胺酮在任何程度上都不影响所测试的PMNL功能。咪达唑仑抑制超氧阴离子的产生（P≤0.01），但只有在使用远远超出临床相关浓度的情况下才会如此。
