Portugal V, García-Alonso I, Barceló P, Méndez J
Department of Surgery, University of The Basque Country, Leioa, Spain.
Eur Surg Res. 1995;27(2):69-76. doi: 10.1159/000129375.
Liver regeneration plays a key role in restoring the liver/body ratio after partial liver transplantation. However, hepatic ischemia hinders the proliferative response of the hepatocytes. In this study, different ways of improving the regenerating capacity of ischemic hepatocytes are tested. Following 70% hepatectomy and 15 min of normothermic liver ischemia, the percentage of regenerating hepatocytes and the regenerative gradient are assessed. Cyclosporine A (hepatotrophic agent), superoxide dismutase and folinic acid (antioxidants), administered during the ischemic period, have significantly increased these indices. The later drug has restored the regenerative response to the levels of normoperfused livers.
肝再生在部分肝移植后恢复肝脏/身体比例方面起着关键作用。然而，肝脏缺血会阻碍肝细胞的增殖反应。在本研究中，测试了提高缺血肝细胞再生能力的不同方法。在70%肝切除和15分钟常温肝脏缺血后，评估再生肝细胞的百分比和再生梯度。在缺血期给予环孢素A（肝细胞营养剂）、超氧化物歧化酶和亚叶酸（抗氧化剂），显著提高了这些指标。后一种药物已将再生反应恢复到正常灌注肝脏的水平。
