Echevarría M I, García-Alonso I, Portugal V, Barceló P, Méndez J
Laboratorio de Ciugía Experimental, Universidad del País Vasco, Vizcaya.
Rev Esp Enferm Dig. 1994 Dec;86(6):894-7.
The aim of this study was to evaluate the efficacy of certain antioxidant and/or hepatotrophic drugs on the sensitivity to ischemia of hepatocytes implanted into the spleen. Twenty four hours after hepatocellular transplantation, animals were submitted to 15 minutes of normotermic ischemia followed by 70% hepatectomy. Hepatocytic function was assessed 24 h later by measuring the intensity of the regenerative response, both in the liver and in the spleen. All drugs increased the percentage of regenerating hepatocytes, but only allopurinol and cyclosporine achieved significance. However none of the drugs were useful for hepatocytes implanted in the spleen, allopurinol having a deleterious effect.
本研究的目的是评估某些抗氧化剂和/或肝细胞营养药物对植入脾脏的肝细胞缺血敏感性的影响。肝细胞移植24小时后，对动物进行15分钟的常温缺血，随后进行70%肝切除术。24小时后通过测量肝脏和脾脏中再生反应的强度来评估肝细胞功能。所有药物均增加了再生肝细胞的百分比，但只有别嘌呤醇和环孢素达到显著水平。然而，没有一种药物对植入脾脏的肝细胞有用，别嘌呤醇具有有害作用。
